Covered Topics

The majority of cells in our body contain the same genomic information. Nevertheless, an organism consists of a variety of cell types that differ in shape and function. This variability can be explained with the central dogma of molecular biology: genes are processed to functional proteins and RNAs via a multi-step process that is highly regulated by a multitude of general and cell-type specific factors. An example for the complexity of gene regulation is embryogenesis, in which regulatory programs orchestrate the development of a functional organism from a single cell. Another example is the formation of genetic diseases like cancer. They can develop by a chain of mutations that are not only located within genes, but also in regulatory parts of the genome. These mutations can affect a variety of regulatory factors, which can alter the activity of genes. Indeed, the mechanisms that regulate gene activity are not fully uncovered yet.

Recent advances in high-throughput technologies and experimental techniques enhanced the possiblities to study gene regulation. However, the resutling experimental data is often complex and high-dimensional. This highlights the necessity of special purpose bioinformatics methods (e.g. in the area of machine learning and statics) that are suitable for analyzing and visualizing the biological data.

This seminar covers a selection of novel and impactful methods in this field. It will be held as a block seminar the week before the lectures start.


Prof. Dr. Hans-Peter Lenhof

Teaching Assistant

Prerequisites Important

Conditions for Certificate


In order to participate in the seminar you are required to attend the first meeting.
There the topics are distributed. No prior reservation is possible.
Due to the corona pandemic, the first meeting will be held via Zoom. If you like to participate, please register via mail (
After you received a topic, please confirm your participation in the seminar until 2021/02/01 via mail to
Also, you have to register officially in HISPOS until 2021/02/15.

1st deadline report
Final deadline report
1st deadline slides
2st deadline slides
2021/04/06 starting at 13:00 s.t. and 2021/04/07 starting at 09:00 s.t. via ZOOM

Checklist for slides

Checklist for report

Supplementary material

  1. Checklist to prevent Plagiarism
  2. Turnitin
  3. Designing effective scientific presentations (Susan McConnell - Stanford)
  4. How to give a great scientific talk (Nature)
  5. How to give a dynamic scientific presentation (Elsevier)
  6. The Craft of Scientific Presentations (Michael Alley)